Prehospital diagnosis of massive ethylene glycol poisoning and use of an early antidote.
نویسندگان
چکیده
We report the case of a patient suspected of voluntary massive poisoning by ethylene glycol. Prehospital diagnosis was established by portable blood analyser and an early antidote with 4 MP treatment initiated in out-of-hospital setting. Use of portable blood analyser in prehospital care should be considered in case of suspected massive poisoning by ethylene glycol.
منابع مشابه
Translational Antidote Research: A Bedside to Bench Tale
Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...
متن کاملEthylene Glycol Poisoning; an Unusual Cause of Hyperglycemia: A Case Report
Background:Poisoning with ethylene glycol (EG) can be fatal even if appropriate treatments are delivered. EG poisoning usually causes central nervous system depression, cardiovascular dysfunction, metabolic acidosis and acute renal failure (ARF). Case Report:A 33-year-old man was referred to the emergency department with reduced consciousness and dyspnea of four-hour duration due to unknown rea...
متن کاملEthylene glycol or methanol intoxication: which antidote should be used, fomepizole or ethanol?
Ethylene glycol (EG) and methanol poisoning can cause life-threatening complications. Toxicity of EG and methanol is related to the production of toxic metabolites by the enzyme alcohol dehydrogenase (ADH), which can lead to metabolic acidosis, renal failure (in EG poisoning), blindness (in methanol poisoning) and death. Therapy consists of general supportive care (e.g. intravenous fluids, corr...
متن کاملEthylene Glycol Characterization
Ethylene glycol is most commonly found as the primary ingredient of automobile antifreeze and hydraulic brake fluids. The major use of ethylene glycol as an antifreeze is namely in automobiles, in air conditioning systems and in as de-icing fluid for windshields. It is a widely used chemical that is capable of causing significant injury if ingested. It is not intrinsically toxic but requires me...
متن کامل2009 NVIC_NJCC 06.indd
Ethanol and fomepizole are used as antidotes for poisoning with ethylene glycol or methanol. Both ethylene glycol and methanol are metabolized by the enzyme alcohol dehydrogenase. Ethanol is a substrate for alcohol dehydrogenase and fomepizole is an inhibitor of this enzyme. This review pays attention to the differences between ethanol and fomepizole. The advantages and disadvantages of both an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Resuscitation
دوره 70 2 شماره
صفحات -
تاریخ انتشار 2006